Brasted P J, Robbins T W, Dunnett S B
Medical Research Council Centre for Brain Repair, University of Cambridge, United Kingdom.
Behav Neurosci. 1999 Apr;113(2):253-64. doi: 10.1037//0735-7044.113.2.253.
This study examined the relative roles of distinct striatal areas in response processing. Rats were trained on a reaction time task that enabled performance on each side of the rat's body to be assessed independently. Rats then received unilateral lesions of the whole dorsal striatum or restricted medial or lateral lesions. Both medial and lateral lesions induced a response bias in contralateral space, but this bias was less severe in rats with medial lesions. Medial striatal lesions led to an increase in premature responses. Lateral striatal lesions produced an increase in late responses. It is suggested that the lateral striatum mediates the selection of responses, and the medial striatum acts to influence inhibitory control over responding. Discrete striatal areas are thus functionally dissociable, but both have a crucial role in the organization of responding in space.
本研究考察了不同纹状体区域在反应加工中的相对作用。对大鼠进行反应时间任务训练，该任务能够独立评估大鼠身体每一侧的表现。然后，大鼠接受整个背侧纹状体的单侧损伤或局限于内侧或外侧的损伤。内侧和外侧损伤均在对侧空间诱发反应偏向，但内侧损伤大鼠的这种偏向较轻。内侧纹状体损伤导致过早反应增加。外侧纹状体损伤导致延迟反应增加。研究表明，外侧纹状体介导反应的选择，而内侧纹状体则影响对反应的抑制控制。因此，离散的纹状体区域在功能上是可分离的，但两者在空间反应组织中都起着关键作用。
