Stanojevic M, Zerjav S, Jevtovic D J, Markovic L J
Institute for Infectious and Tropical Diseases CCS, University of Belgrade, Yugoslavia.
Biomed Pharmacother. 2000 Apr;54(3):163-7. doi: 10.1016/S0753-3322(00)89049-6.
Seeing the same transmission pattern of HIV and HBV coinfection by these two agents is not an uncommon feature. Immunity impairment due to HIV infection can be the cause of a higher rate of HBV replication with less intensive liver damage and less effective immune response to HBV, while the pathological course in both infections involves elevated levels of circulating immune complexes (CIC). These were the reasons for us to examine the frequency of HBsAg involvement as the antigen component of circulating immune complexes formed in sera of HIV-infected patients in different stages of HIV disease. We tested 67 sera of HIV-positive patients in different stages of HIV disease for the presence of HBsAg and HIV antigen p24 (with and without acid dissociation of immune complexes), for the presence of anti-Hbc antibodies and circulating immune complexes. HBsAg was positive in 13.8% sera prior to and 33.8% after acid pretreatment. Anti-HBc antibodies were present in 76.9% serum samples tested. Fifty percent of sera were positive for both HBsAg and p24 antigen after dissociation of immune complexes. The level of CIC was elevated in 65.9% of sera. Our results suggest that HBsAg is commonly associated in immune complexes formed in the sera of HIV-infected patients and that they may simultaneously contain HIV and HBsAg in patients coinfected with both agents. This may contribute to their mutual interaction and influence the diagnosis and follow-up of patients.
这两种病原体导致的HIV和HBV合并感染呈现相同的传播模式并非罕见特征。HIV感染所致的免疫损伤可能是HBV复制率较高、肝损伤较轻且对HBV免疫反应较弱的原因，而两种感染的病理过程均涉及循环免疫复合物（CIC）水平升高。这些就是我们研究在HIV疾病不同阶段的HIV感染患者血清中形成的循环免疫复合物的抗原成分中HBsAg参与频率的原因。我们检测了67份处于HIV疾病不同阶段的HIV阳性患者血清，以检测HBsAg和HIV抗原p24的存在情况（免疫复合物有无酸解离）、抗-Hbc抗体和循环免疫复合物的存在情况。酸预处理前13.8%的血清中HBsAg呈阳性，酸预处理后为33.8%。检测的血清样本中有76.9%存在抗-HBc抗体。免疫复合物解离后，50%的血清中HBsAg和p24抗原均呈阳性。65.9%的血清中CIC水平升高。我们的结果表明，HBsAg通常与HIV感染患者血清中形成的免疫复合物相关，并且在这两种病原体合并感染的患者中，免疫复合物可能同时含有HIV和HBsAg。这可能有助于它们之间的相互作用，并影响患者的诊断和随访。
