Latner A L, Turner G A
Br J Cancer. 1976 May;33(5):535-8. doi: 10.1038/bjc.1976.84.
Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice. A second tumour graft in tumour-bearing hamsters appeared more rapidly than the first. Prior administration of aprotinin abolished this effect. Pretreatment of non-cancerous mice with cortisone nullified the effectiveness of aprotinin in inhibiting the growth of a subsequent tumour graft. These results are interpreted as additional evidence that aprotinin enhances the immunological system against tumour cells.
先前的研究表明，抑肽酶可能会增强宿主对肿瘤的免疫抵抗力。现在，通过研究仓鼠和小鼠体内肿瘤的行为，对这种可能性进行了进一步调查。在荷瘤仓鼠中进行的第二次肿瘤移植比第一次出现得更快。预先给予抑肽酶消除了这种效应。用可的松对非癌小鼠进行预处理，使抑肽酶抑制后续肿瘤移植生长的效果失效。这些结果被解释为抑肽酶增强针对肿瘤细胞的免疫系统的额外证据。
