糖皮质激素对巨噬细胞移动抑制因子的抑制作用
Glucocorticoid suppression of macrophage migration inhibitory factor.
作者信息
Balow J E, Rosenthal A S
出版信息
J Exp Med. 1973 Apr 1;137(4):1031-41. doi: 10.1084/jem.137.4.1031.
Abstract
The ability of hydrocortisone to modify antigen-mediated inhibition of macrophage migration, an in vitro correlate of cellular immunity in the guinea pig, was investigated. Only the glucocorticoids, hydrocortisone and dexamethasone, significantly blocked migration inhibitory factor (MIF) activity in pharmacologic concentrations. Hydrocortisone had no effect on antigen "processing" by macrophages, nor on the ability of antigen-stimulated peritoneal exudate lymphocytes to produce MIF. Rather, hydrocortisone antagonized directly the inhibitory effect of MIF on the macrophage.
摘要
研究了氢化可的松改变抗原介导的巨噬细胞迁移抑制的能力，这是豚鼠细胞免疫的一种体外相关指标。只有糖皮质激素，即氢化可的松和地塞米松，在药理浓度下能显著阻断迁移抑制因子（MIF）的活性。氢化可的松对巨噬细胞的抗原“加工”没有影响，对抗原刺激的腹腔渗出淋巴细胞产生MIF的能力也没有影响。相反，氢化可的松直接拮抗MIF对巨噬细胞的抑制作用。
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