Prokopenko L G, Drobiazgo L D
Biull Eksp Biol Med. 1975 May;79(5):83-5.
Antibodies to erythrocytes of sheep and human serum albumin were formed in rabbits with alimentary atherosclerosis as intensively as in control. Trasilol failed to affect the antibody formation in normal animals, but sharply decreased the production of specific immunoglobulins (especially the 7S) in rabbits with experimental atherosclerosis. Thus, the action of the preparation is realized not by way of direct inhibition of functional activity of the lymphoid tissue cells, but by inhibiting the immunostimulating factor circulating in the blood in experimental atherosclerosis.
在患有营养性动脉粥样硬化的兔子体内，针对绵羊红细胞和人血清白蛋白的抗体形成与对照组一样强烈。抑肽酶对正常动物的抗体形成没有影响，但在患有实验性动脉粥样硬化的兔子中，它能显著降低特异性免疫球蛋白（尤其是7S）的产生。因此，该制剂的作用不是通过直接抑制淋巴组织细胞的功能活性来实现的，而是通过抑制实验性动脉粥样硬化中血液中循环的免疫刺激因子来实现的。
