Beutler J A, McCall K L, Herbert K, Herald D L, Pettit G R, Johnson T, Shoemaker R H, Boyd M R
Laboratory of Drug Discovery Research & Development, Developmental Therapeutics Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute-FCRDC, Bldg. 1052, Rm. 121, Frederick, Maryland 21702-1201, USA.
J Nat Prod. 2000 May;63(5):657-61. doi: 10.1021/np990553r.
Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.
对树酪梨树根的二氯甲烷 - 甲醇提取物进行细胞毒性导向分级分离，得到了五种新型克罗烷二萜类化合物，即树酪梨素A - E（1 - 5），以及葫芦素B。还检测到了葫芦素糖苷的存在。通过X射线晶体学确定了树酪梨素E的绝对构型。
