麦卡拉米德D，一种从新西兰海洋海绵迈卡拉属物种中分离出的新型细胞毒性酰胺。
Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.
作者信息
West L M, Northcote P T, Hood K A, Miller J H, Page M J
机构信息
School of Chemical and Physical Sciences, Victoria University of Wellington, New Zealand.
出版信息
J Nat Prod. 2000 May;63(5):707-9. doi: 10.1021/np9904511.
PMID:10843597
Abstract
A new mycalamide, mycalamide D (3), has been isolated from the New Zealand marine sponge Mycale sp. This new metabolite, in which the C13-O-methyl group of mycalamide A (1) is replaced by a hydrogen atom, was found to be cytotoxic to a range of mammalian cell lines, with a potency approximately 20-fold less than that of 1.
摘要
一种新的海绵酰胺，海绵酰胺D（3），已从新西兰海洋海绵Mycale sp.中分离出来。这种新的代谢产物中，海绵酰胺A（1）的C13 - O - 甲基被一个氢原子取代，被发现对一系列哺乳动物细胞系具有细胞毒性，其效力比1低约20倍。
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