Matsunaga S, Sugawara T, Fusetani N
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
J Nat Prod. 1998 Sep;61(9):1164-7. doi: 10.1021/np980102r.
Three new macrolides, 30-hydroxymycalolide A (4), 32-hydroxymycalolide A (5), and 38-hydroxymycalolide B (6), were isolated from the marine sponge Mycale magellanica. Their structures were assigned on the basis of spectroscopic data. They were cytotoxic against L1210 cells with IC50 values of 0.019, 0.013, and 0.015 microg/mL, respectively. Chemical interconversion of the known mycalolides A-C (1-3) with 4-6 established their stereochemical relationships.
从海洋海绵麦哲伦扁海绵（Mycale magellanica）中分离出三种新的大环内酯类化合物，即30-羟基麦卡洛内酯A（4）、32-羟基麦卡洛内酯A（5）和38-羟基麦卡洛内酯B（6）。它们的结构是根据光谱数据确定的。它们对L1210细胞具有细胞毒性，IC50值分别为0.019、0.013和0.015微克/毫升。已知的麦卡洛内酯A-C（1-3）与4-6的化学相互转化确定了它们的立体化学关系。
