Matsunaga S, Nogata Y, Fusetani N
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
J Nat Prod. 1998 May;61(5):663-6. doi: 10.1021/np9704866.
Two new cytotoxic trisoxazole macrolides, thiomycalolides A (2) and B (3), have been isolated from a marine sponge Mycale sp. The structures were determined to be glutathione adducts of mycalolides A and B by interpretation of spectral data and chemical transformation. Thiomycalolides A and B are highly cytotoxic against P388 murine leukemia cells.
从一种海洋海绵Mycale sp.中分离出了两种新的具有细胞毒性的三恶唑大环内酯类化合物，硫麦考内酯A（2）和硫麦考内酯B（3）。通过光谱数据解析和化学转化确定其结构为麦考内酯A和B的谷胱甘肽加合物。硫麦考内酯A和B对P388小鼠白血病细胞具有高度细胞毒性。
