Flisiak R, Pytel-Krolczuk B, Prokopowicz D
Department of Infectious Diseases, Medical Academy of Bialystok, Bialystok, Poland.
Cytokine. 2000 Jun;12(6):677-81. doi: 10.1006/cyto.1999.0660.
In the liver, transforming growth factor (TGF) -beta(1)is primarily responsible for activation of fat-storing cells, which are the main source of extracellular matrix proteins. Their deposition play a key role in the development of liver cirrhosis. The aim of this study was to evaluate plasma TGF-beta(1)in patients with different stages of liver cirrhosis and its possible use as an indicator of liver function impairment. TGF-beta(1)was measured in the plasma of 40 patients with liver cirrhosis. To estimate possible effect of liver insufficiency on plasma TGF-beta(1), patients were divided into three groups: A, B and C, univocal with Child-Pugh classes. Normal values were collected from 13 healthy volunteers. Liver cirrhosis resulted in a significant increase of plasma concentration of TGF-beta(1)(39.3+/-3.8 ng/ml), which doubled normal values (18.3+/-1.6 ng/ml). The highest concentrations were observed in alcoholic patients (44.4+/-4.7 ng/ml). TGF-beta(1)level increased depending on the degree of liver insufficiency, demonstrated by a significant positive correlation with Child-Pugh score (r=0.591). Values in group A were similar to normal, but were significantly elevated in groups B and C. These findings suggest possible use of plasma TGF-beta(1)measurement as an indicator of liver function impairment and possible marker of hepatic fibrosis progression in cirrhotic patients.
在肝脏中，转化生长因子（TGF）-β1主要负责激活贮脂细胞，而贮脂细胞是细胞外基质蛋白的主要来源。它们的沉积在肝硬化的发展过程中起关键作用。本研究的目的是评估不同阶段肝硬化患者的血浆TGF-β1水平及其作为肝功能损害指标的可能性。检测了40例肝硬化患者血浆中的TGF-β1。为评估肝功能不全对血浆TGF-β1的可能影响，将患者分为A、B、C三组，分别对应Child-Pugh分级。从13名健康志愿者中收集了正常值。肝硬化导致血浆TGF-β1浓度显著升高（39.3±3.8 ng/ml），是正常值（18.3±1.6 ng/ml）的两倍。酒精性肝病患者的浓度最高（44.4±4.7 ng/ml）。TGF-β1水平随肝功能不全程度的增加而升高，与Child-Pugh评分呈显著正相关（r = 0.591）。A组的值与正常相似，但B组和C组显著升高。这些发现表明，检测血浆TGF-β1可能作为肝硬化患者肝功能损害的指标以及肝纤维化进展的可能标志物。
