Lichter H, Loya N, Sagie A, Cohen N, Muzmacher L, Yassur Y, Weinberger D
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
Am J Ophthalmol. 2000 May;129(5):667-8. doi: 10.1016/s0002-9394(00)00371-8.
To investigate the prevalence of keratoconus in patients with mitral valve prolapse (MVP).
Videokeratography was performed in 36 patients (72 eyes) with an echocardiographic diagnosis of MVP, and were compared with 25 controls. All participants underwent slit-lamp examination and completed a medical questionnaire about joint hypermobility, arthralgia, asthma, and allergic reactions.
Keratoconus was found in eight eyes (11. 1%) (P =.056) of eight patients (22.2%) (P =.049) in the MVP group and in one eye (2%) of one patient (4%) in the control group. The keratoconus was unilateral and asymptomatic in all cases. Conjunctival papillae were statistical significant higher in the MVP group (P =.015). A statistically significant intergroup difference existed in the presence of an allergic reaction (P =.001), but not in arthralgia, hypermobility of joints, or asthma.
A borderline important association of MVP with keratoconus and with allergy exists. Patients with mitral valve prolapse complaining of poor vision should be suspected of having keratoconus.
研究二尖瓣脱垂（MVP）患者圆锥角膜的患病率。
对36例经超声心动图诊断为MVP的患者（72只眼）进行角膜地形图检查，并与25名对照者进行比较。所有参与者均接受裂隙灯检查，并完成一份关于关节活动过度、关节痛、哮喘和过敏反应的医学问卷。
MVP组中8例患者（22.2%）（P = 0.049）的8只眼（11.1%）（P = 0.056）发现圆锥角膜，对照组中1例患者（4%）的1只眼（2%）发现圆锥角膜。所有病例的圆锥角膜均为单侧且无症状。MVP组结膜乳头在统计学上显著更高（P = 0.015）。过敏反应的存在存在统计学上的组间显著差异（P = 0.001），但关节痛、关节活动过度或哮喘方面不存在差异。
MVP与圆锥角膜和过敏之间存在临界重要关联。主诉视力不佳的二尖瓣脱垂患者应怀疑患有圆锥角膜。
