Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cornea. 2011 Feb;30(2):154-7. doi: 10.1097/ICO.0b013e3181e846a2.
To investigate the association between corneal hydrops in patients with keratoconus (KCN) and mitral valve prolapse (MVP).
This case-control study included patients with KCN with corneal hydrops who were referred to Labbafinejad Medical Center or a private clinic between March 2006 and March 2008, as the case group. The control group included group-matched individuals who were selected from patients of the same medical centers without any ophthalmic diseases. The size of the control group was 4 times that of the case group to increase the power of the study. All subjects were referred for cardiac examination and underwent 2-dimensional, M-mode, and color Doppler echocardiography. The criteria of Perloff et al were used for diagnosis of MVP. Fisher exact test and logistic regression analysis were used to compare these 2 groups.
Overall, 160 participants (32 cases and 128 controls) with mean age of 31.0 ± 13.2 years were studied. Prevalence of MVP was 65.6% in the case group and 9% in controls (P < 0.001). Patients with hydrops had an odds ratio of 26.7 for having MVP (95% confidence interval, 9.5-75.2). Age- and sex-adjusted analyses revealed that the odds ratio of MVP in the case group was higher than that in the control group.
There seems to be a correlation between corneal hydrops secondary to KCN and MVP, suggesting further evaluation to assess mitral valve status.
研究圆锥角膜（KCN）伴角膜水肿患者与二尖瓣脱垂（MVP）之间的相关性。
本病例对照研究纳入了 2006 年 3 月至 2008 年 3 月期间因 KCN 伴角膜水肿而转诊至拉巴菲纳德医疗中心或私人诊所的患者作为病例组。对照组为来自同一医疗中心且无任何眼部疾病的患者，其人数是病例组的 4 倍，以增强研究的效力。所有患者均接受了心脏检查，并进行了二维、M 型和彩色多普勒超声心动图检查。采用 Perloff 等人的标准诊断 MVP。采用 Fisher 确切检验和逻辑回归分析比较两组。
共有 160 名参与者（32 例病例和 128 名对照）纳入研究，平均年龄为 31.0±13.2 岁。病例组 MVP 的患病率为 65.6%，对照组为 9%（P<0.001）。伴水肿的患者发生 MVP 的优势比为 26.7（95%置信区间，9.5-75.2）。年龄和性别调整分析显示，病例组 MVP 的优势比高于对照组。
KCN 继发角膜水肿与 MVP 之间似乎存在相关性，提示进一步评估以评估二尖瓣状态。
