Helder A W, Feltkamp-Vroom T M
J Pathol. 1976 May;119(1):49-56. doi: 10.1002/path.1711190108.
Tissues obtained at random from patients suffering from autoimmune and non-autoimmune diseases were studied for the presence of tubuloreticular structures (TRS). It could be demonstrated that the occurrence of TRS in renal tissue is not a specific characteristic of systemic lupus erythematosus whereas the presence of such structures in skin tissue might be suggestive for this disease. The serum of some of the patients could be studied for the presence of antinuclear antibodies (ANA). A statistically significant correlation was found between TRS and ANA in the group of patients with autoimmune diseases. The possibility is discussed that this correlation might favour the theory that viruses may be involved in the aetiology of autoimmune diseases, particularly of systemic lupus erythematosus.
从患有自身免疫性疾病和非自身免疫性疾病的患者身上随机获取组织，研究其中是否存在管网状结构（TRS）。结果表明，肾组织中TRS的出现并非系统性红斑狼疮的特异性特征，而皮肤组织中出现此类结构可能提示患有该疾病。对部分患者的血清进行抗核抗体（ANA）检测。在自身免疫性疾病患者组中，发现TRS与ANA之间存在统计学上的显著相关性。文中讨论了这种相关性可能支持病毒参与自身免疫性疾病，尤其是系统性红斑狼疮病因学的理论这一可能性。
