铜绿假单胞菌突变体在小鼠和昆虫体内的毒力之间存在正相关。
Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.
作者信息
Jander G, Rahme L G, Ausubel F M
机构信息
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
出版信息
J Bacteriol. 2000 Jul;182(13):3843-5. doi: 10.1128/JB.182.13.3843-3845.2000.
Abstract
Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.
摘要
菌株PA14是铜绿假单胞菌的一种人类临床分离株，对小鼠和昆虫（大蜡螟）具有致病性。对这两种宿主中的32种不同PA14突变体的分析表明，毒力模式存在一种新的正相关关系。因此，大蜡螟是鉴定铜绿假单胞菌哺乳动物毒力因子的良好模型系统。
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