Rawson A J, Huang T C
Arthritis Rheum. 1976 Jul-Aug;19(4):720-4. doi: 10.1002/1529-0131(197607/08)19:4<720::aid-art1780190410>3.0.co;2-5.
For each of 28 patients with RA and 27 normal controls, the in vitro lymphocyte responses to PHA and to Con A were simultaneously determined on aliquots of the same cell preparation. In the case of RA lymphocytes, the response to Con A was abnormally low when compared with the simultaneous response to PHA (P less than 0.01). Cells capable of responding to PHA were specifically killed with BUdR. The cells remaining after this procedure showed a relatively greater response to Con A than did the original population. In the case of RA lymphocytes, this relative increase in the response to Con A was significantly less than normal (0.02 greater than P greater than 0.01). These results suggest that a lymphocyte subpopulation, responding principally to Con A, is relatively reduced in RA.
对28例类风湿关节炎（RA）患者和27名正常对照者，在同一份细胞制剂的等分试样上同时测定了对PHA和Con A的体外淋巴细胞反应。对于RA淋巴细胞，与同时对PHA的反应相比，对Con A的反应异常低（P小于0.01）。用溴脱氧尿苷（BUdR）特异性杀死能够对PHA作出反应的细胞。此操作后剩余的细胞对Con A的反应比原始细胞群相对更大。对于RA淋巴细胞，对Con A反应的这种相对增加明显低于正常水平（0.02大于P大于0.01）。这些结果表明，主要对Con A作出反应的淋巴细胞亚群在RA中相对减少。
