Chattopadhyay C, Chattopadhyay H, Natvig J B, Mellbye O J
Scand J Immunol. 1979;10(5):479-86. doi: 10.1111/j.1365-3083.1979.tb01378.x.
Synovial lymphocytes eluted by enzyme treatment from eleven patients with rheumatoid arthritis (RA) were investigated for the presence of concanavalin A (Con A)-activated suppressor cell activity as compared with that of peripheral blood lymphocytes of twenty normal donors. In addition, two patients with psoriatic arthritis and juvenile rheumatoid arthritis (JRA) were also investigated. Synovial lymphocytes from the eleven RA patients showed a mean augmentation of 28 +/- 13.30, and thus clearly lacked suppressor activity, whereas the mean suppression in the lymphocytes from the twenty normal donors was 13 +/- 14.40. Synovial lymphocytes from one patient with JRA and one with psoriatic arthritis showed a normal suppressor activity.
从11例类风湿性关节炎（RA）患者中通过酶处理洗脱的滑膜淋巴细胞，与20名正常供体的外周血淋巴细胞相比，研究其是否存在伴刀豆球蛋白A（Con A）激活的抑制细胞活性。此外，还对2例银屑病关节炎和青少年类风湿性关节炎（JRA）患者进行了研究。11例RA患者的滑膜淋巴细胞平均增强率为28±13.30，因此明显缺乏抑制活性，而20名正常供体淋巴细胞的平均抑制率为13±14.40。1例JRA患者和1例银屑病关节炎患者的滑膜淋巴细胞表现出正常的抑制活性。
