病毒特异性T细胞介导的细胞溶解的H-2相容性要求。评估H-2I区域和非H-2基因在调节免疫反应中的作用。
H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. Evaluation of the role of H-2I region and non-H-2 genes in regulating immune response.
作者信息
Zinkernagel R M, Dunlop M B, Blanden R V, Doherty P C, Shreffler D C
出版信息
J Exp Med. 1976 Aug 1;144(2):519-32. doi: 10.1084/jem.144.2.519.
Abstract
Lymphocytic choriomeningitis virus (LCMV) and ectromelia virus-specific T-cell-mediated cytotoxicity was assayed in various strain combinations using as targets peritoneal macrophages which have been shown to express Ia antigens. Virus-specific cytotoxicity was found only in H-2K- or D-region compatible combinations. I-region compatibility was not necessary nor alone sufficient for lysis. Six different I-region specificities had no obvious effect on the capacity to generate in vivo specific cytotoxicity (expressed in vitro) associated with Dd. Low LCMV-specific cytotoxic activity generated in DBA/2 mice was caused by the non-H-2 genetic background. This trait was inversely related to the infectious virus dose and recessive. Non-H-2 genes, possibly involved in controlling initial spread and multiplication of virus, seem to be, at least in the examples tested, more important in determining virus-specific cytotoxic T-cell activity in spleens than are Ir genes coded in H-2.
摘要
利用已被证明能表达Ia抗原的腹腔巨噬细胞作为靶细胞，在各种品系组合中检测淋巴细胞性脉络丛脑膜炎病毒（LCMV）和痘苗病毒特异性T细胞介导的细胞毒性。仅在H-2K或D区相容的组合中发现病毒特异性细胞毒性。I区相容性对于裂解既非必需，单独存在时也不充分。六种不同的I区特异性对产生与Dd相关的体内特异性细胞毒性（体外表达）的能力没有明显影响。DBA/2小鼠中产生的低LCMV特异性细胞毒性活性是由非H-2遗传背景引起的。这一特性与感染性病毒剂量呈负相关且为隐性。非H-2基因可能参与控制病毒的初始传播和增殖，至少在所测试的例子中，在决定脾脏中病毒特异性细胞毒性T细胞活性方面，似乎比H-2编码的Ir基因更重要。
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