Griffin F M, Griffin J A, Silverstein S C
J Exp Med. 1976 Sep 1;144(3):788-809. doi: 10.1084/jem.144.3.788.
We have examined the effect of the distribution of anti-immunoglobulin IgG molecules on the surface of bone marrow-derived lymphocytes upon the interaction of these cells with macrophages. Lymphocytes which were diffusely coated with antibodies to surface immunoglogulin were ingested by macrophages. Lymphocytes which had the same number of anti-immunoglobulin IgG molecules redistributed to one pole of the surface bound to the macrophages' Fc receptors but were not ingested. These results confirm our previous hypothesis that ingestion of an immunologically coated particle requires the sequential, circumferential binding of specific receptors on the plasma membrane of a phagocytic cell to immunologic ligands distributed over the entire particle surface. Macrophages which had bound capped lymphocytes by the macrophages' Fc receptors removed the immune complex caps from the lymphocyte surface without destroying the lymphocytes. These lymphocytes remained attached to the macrophage surface. The finding that macrophages can phagocytize immune complexes from the surface of a cell without destroying the cell to which these complexes are attached may be important in understanding the effects of antigens and antibodies on cells participating in a humoral immune response, in identifying the mechanisms by which chronic viral infections are established, and in defining the roles of blocking antibodies in tumor immunity.
我们研究了骨髓来源的淋巴细胞表面抗免疫球蛋白IgG分子的分布在这些细胞与巨噬细胞相互作用时所产生的影响。被表面免疫球蛋白抗体弥漫性包被的淋巴细胞会被巨噬细胞吞噬。具有相同数量抗免疫球蛋白IgG分子但重新分布到与巨噬细胞Fc受体结合的表面一极的淋巴细胞则不会被吞噬。这些结果证实了我们之前的假设，即吞噬免疫包被颗粒需要吞噬细胞质膜上的特异性受体与分布在整个颗粒表面的免疫配体进行顺序性的周向结合。通过巨噬细胞Fc受体结合了帽状淋巴细胞的巨噬细胞会从淋巴细胞表面去除免疫复合物帽，而不会破坏淋巴细胞。这些淋巴细胞仍附着在巨噬细胞表面。巨噬细胞能够从细胞表面吞噬免疫复合物而不破坏复合物所附着的细胞，这一发现对于理解抗原和抗体对参与体液免疫反应的细胞的影响、确定慢性病毒感染的建立机制以及界定阻断抗体在肿瘤免疫中的作用可能具有重要意义。
