Pol S, Zylberberg H
Unité d'Hépatologie, Hôpital Necker, Paris.
Ann Med Interne (Paris). 2000 Apr;151 Suppl A:A33-9.
Management of viral hepatitis in drug uses must follow a multidisciplinary approach within the framework of overall psychosocial, alcohologic, and medical care. Substitution is an important but not indispensable aspect. In patients who have achieved social, psychological and medical stability (possible initiation of antiretroviral treatment), antiviral treatments can be started and followed in the same way as for other patients. Prescriptions should aim at improving the liver disease and avoid progression to cirrhosis and complications. Ribavirin/interferon-alfa appears to be the combination of choice for first line treatment of hepatitis C (while waiting for combinations with protease inhibitors). Anti-HBV vaccination is the treatment of choice for the prevention of hepatitis B and D. Coordination and information sharing between health and social care partners is crucial for the management of these patients.
药物使用中病毒性肝炎的管理必须在整体心理社会、酒精相关问题及医疗护理的框架内采取多学科方法。替代疗法是一个重要但并非不可或缺的方面。对于已实现社会、心理和医疗稳定（可能开始抗逆转录病毒治疗）的患者，可像其他患者一样开始并进行抗病毒治疗。处方应旨在改善肝病，避免进展为肝硬化和出现并发症。利巴韦林/干扰素-α似乎是丙型肝炎一线治疗的首选联合用药（同时等待与蛋白酶抑制剂的联合用药）。抗乙肝病毒疫苗接种是预防乙型和丁型肝炎的首选治疗方法。卫生保健和社会护理伙伴之间的协调与信息共享对于这些患者的管理至关重要。
