Veien N K, Hardt F, Bendixen G, Ringsted J, Brodthagen H, Faber V, Genner J, Heckscher T, Svejgaard A, Freisleben Sorensen S, Wanstrup J, Wiik A
Ann N Y Acad Sci. 1976;278:47-51. doi: 10.1111/j.1749-6632.1976.tb47015.x.
We found it valuable to separate the heterogeneous types of sarcoidosis into more homogeneous groups on the basis of activity and duration of the disease. This view is supported in the present study by the finding of a marked depression of T-cell function in patients with chronic-active sarcoidosis. Patients with acute or chronic-inactive disease had only moderately depressed T-cell function as measured by tuberculin skin test and DNCB index. These results are in agreement with those of some previous investigations. The remainder of the abnormal findings, particularly low total number of circulation T lymphocytes, elevated serum IgG levels, and presence of autoantibodies, could not be correlated to disease activity, extent of the disease, or T-cell function. We have found no explanation for the presence of autoantibodies but suspect that they may be nonspecifically related to the disease process.
我们发现，根据疾病的活动度和病程，将结节病的异质类型分为更同质的组很有价值。本研究中，慢性活动性结节病患者T细胞功能显著降低这一发现支持了这一观点。通过结核菌素皮肤试验和二硝基氯苯指数测量，急性或慢性非活动性疾病患者的T细胞功能仅中度降低。这些结果与之前一些研究的结果一致。其余异常发现，特别是循环T淋巴细胞总数低、血清IgG水平升高和自身抗体的存在，与疾病活动度、疾病范围或T细胞功能无关。我们尚未找到自身抗体存在的原因，但怀疑它们可能与疾病过程非特异性相关。
