Dolin R, Reichman R C, Fauci A S
Infect Immun. 1976 Aug;14(2):422-8. doi: 10.1128/iai.14.2.422-428.1976.
Viral gastroenteritis was induced in 16 of 24 normal volunteers after oral administration of either the Norwalk or Hawaii agents. Clinical illness lasted for 24 to 48 h and resolved spontaneously. During acute illness, a transient lymphopenia was noted which involved all lymphocyte subpopulations (thymus-and bone marrow-derived, and null cells). No circulating lymphocytotoxins were detected, and the lymphocytes remaining in the circulation responded normally to mitogenic stimuli. The acute lymphopenia occurred at the time that mononuclear cell infiltration of the jejunal mucosa has been noted. These findings are consistent with the occurrence of a redistribution of circulating lymphocytes during acute illness, with accumulation of lymphocytes at the site of infection in the gut.
24名正常志愿者中，有16人在口服诺沃克病毒或夏威夷病毒制剂后诱发了病毒性肠胃炎。临床疾病持续24至48小时后自行缓解。在急性发病期间，发现有短暂的淋巴细胞减少，累及所有淋巴细胞亚群（胸腺和骨髓来源的细胞以及裸细胞）。未检测到循环淋巴细胞毒素，循环中剩余的淋巴细胞对促有丝分裂刺激反应正常。急性淋巴细胞减少发生在空肠粘膜单核细胞浸润被发现之时。这些发现与急性疾病期间循环淋巴细胞重新分布、淋巴细胞在肠道感染部位积聚的情况相符。
