Yong-Liang G, Robaey P, Karayanidis F, Bourassa M, Pelletier G, Geoffroy G
Laboratoire de Psychophysiologie Cognitive et de Neuropsychiatrie, Hôpital Sainte-Justine, Université de Montréal, Canada.
Brain Cogn. 2000 Jun-Aug;43(1-3):215-20.
In order to study the behavioral responses and the brain inhibition process in children with attention-deficit hyperactivity disorder (ADHD), Event-Related Potentials (ERPs) were recorded from 30 scalp electrodes in 21 ADHD and 21 normal boys during performing a Go/No-go task. ADHD children made fewer correct responses to both Go and No-go stimuli than normal controls. The frontal N2 amplitude was larger for No-go stimuli than Go stimuli in both groups, reflecting inhibition of responding. Smaller N2 amplitudes to No-go stimuli were found in ADHD children, but only when the Go/No-go task was performed after a first stimulus-response compatibility (SRC) task. In addition, the controls exhibited a prolonged N2 only when the Go/No-go task was performed second. However, the ADHD subjects exhibited this prolonged N2 when the task was first, but not when it was second. These results suggest an inhibitory regulation problem rather an inhibition deficit in ADHD children.
为了研究注意缺陷多动障碍（ADHD）儿童的行为反应和大脑抑制过程，在21名ADHD男孩和21名正常男孩执行“是/否”任务期间，从30个头皮电极记录了事件相关电位（ERP）。ADHD儿童对“是”和“否”刺激的正确反应均少于正常对照组。两组中，“否”刺激的额叶N2波幅均大于“是”刺激，反映了反应抑制。ADHD儿童对“否”刺激的N2波幅较小，但仅在第一个刺激-反应相容性（SRC）任务后执行“是/否”任务时出现。此外，仅在第二个执行“是/否”任务时，对照组的N2波延长。然而，ADHD受试者在第一个执行该任务时出现这种N2波延长，而在第二个执行时则没有。这些结果表明，ADHD儿童存在抑制调节问题，而非抑制缺陷。
