大肠杆菌ClyA蛋白对原代及培养的单核细胞和巨噬细胞的杀细胞及凋亡作用。
Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages.
作者信息
Lai X H, Arencibia I, Johansson A, Wai S N, Oscarsson J, Kalfas S, Sundqvist K G, Mizunoe Y, Sjöstedt A, Uhlin B E
机构信息
Department of Microbiology, Umeå University, S-901 87 Umeå, Sweden.
出版信息
Infect Immun. 2000 Jul;68(7):4363-7. doi: 10.1128/IAI.68.7.4363-4367.2000.
Abstract
Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were cytotoxic and apoptogenic to fresh as well as cultured human and murine monocytes/macrophages.
摘要
溶细胞素A（ClyA）是新发现的大肠杆菌K-12溶细胞蛋白，可介导溶血表型。我们在此表明，高度纯化的ClyA和表达ClyA的大肠杆菌对新鲜以及培养的人源和鼠源单核细胞/巨噬细胞具有细胞毒性并能诱导凋亡。
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