通向细胞凋亡的信号转导通路。

Signal transduction pathways to apoptosis.

作者信息

McConkey D J, Orrenius S

机构信息

Department of Cell Biology, Box 173, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

出版信息

Trends Cell Biol. 1994 Oct;4(10):370-5. doi: 10.1016/0962-8924(94)90087-6.

DOI:10.1016/0962-8924(94)90087-6

PMID:14731626

Abstract

Recent work has demonstrated that a number of signalling events, including cytosolic Ca(2+) rises, cAMP accumulation, activation of protein kinase C, activation of protein tyrosine kinases, and production of ceramide, regulate apoptosis in diverse model systems. However, in some cells these signals promote apoptosis, whereas in others they block the response. This review discusses these observations and proposes explanations for how a given set of signal transduction systems might be involved in multiple cellular responses.

摘要

近期研究表明，包括胞质Ca(2+)升高、cAMP积累、蛋白激酶C激活、蛋白酪氨酸激酶激活以及神经酰胺生成在内的一系列信号转导事件，在多种模型系统中调节细胞凋亡。然而，在某些细胞中这些信号促进细胞凋亡，而在另一些细胞中它们则阻断细胞反应。本文综述了这些观察结果，并对一组特定的信号转导系统如何参与多种细胞反应提出了解释。