Javitt D C
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Audiol Neurootol. 2000 May-Aug;5(3-4):207-15. doi: 10.1159/000013882.
Event-related potentials provide an objective index of neurocognitive dysfunction in schizophrenia. Schizophrenia subjects show a decreased mismatch negativity (MMN) amplitude relative to age- and sex-matched controls, along with a characteristic pattern of MMN dysfunction across conditions. Deficits in MMN generation are accompanied by (1) impaired precision of auditory sensory memory performance and (2) an interstimulus-interval-dependent deficit in auditory N(1) generation. Similar deficits are observed following systemic or local infusion of N-methyl-D-aspartate (NMDA) antagonists, supporting glutamatergic and phencyclidine/NMDA models of the disorder. Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia.
事件相关电位为精神分裂症的神经认知功能障碍提供了一个客观指标。与年龄和性别匹配的对照组相比，精神分裂症患者的失匹配负波（MMN）波幅降低，且在不同条件下MMN功能障碍具有特征性模式。MMN产生缺陷伴有：（1）听觉感觉记忆表现的精确性受损；（2）听觉N(1)产生过程中依赖刺激间隔的缺陷。在全身或局部注射N-甲基-D-天冬氨酸（NMDA）拮抗剂后也观察到类似缺陷，这支持了该疾病的谷氨酸能和苯环利定/NMDA模型。局灶性皮质损伤，尤其是背外侧前额叶皮质损伤后，也可能出现MMN产生缺陷。因此，MMN为研究精神分裂症脑功能障碍的潜在机制提供了一个有用的工具。
