Univ. Grenoble Alpes, F-38000 Grenoble, France; INSERM, U1216, F-38000 Grenoble, France; Psychiatry Department, CHU Grenoble Alpes, F-38000 Grenoble, France; Psychiatry Department, CH Alpes-Isère, F-38000 Saint-Egrève, France.
Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, United States; Schizophrenia Research Center, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States.
Neurosci Biobehav Rev. 2023 May;148:105098. doi: 10.1016/j.neubiorev.2023.105098. Epub 2023 Feb 14.
Schizophrenia is a major mental disorder that affects approximately 1% of the population worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long-term disability. Over the past decades, significant literature has accumulated demonstrating impairments in early auditory perceptual processes in schizophrenia. In this review, we first describe early auditory dysfunction in schizophrenia from both a behavioral and neurophysiological perspective and examine their interrelationship with both higher order cognitive constructs and social cognitive processes. Then, we provide insights into underlying pathological processes, especially in relationship to glutamatergic and N-methyl-D-aspartate receptor (NMDAR) dysfunction models. Finally, we discuss the utility of early auditory measures as both treatment targets for precision intervention and as translational biomarkers for etiological investigation. Altogether, this review points out the crucial role of early auditory deficits in the pathophysiology of schizophrenia, in addition to major implications for early intervention and auditory-targeted approaches.
精神分裂症是一种主要的精神障碍，影响着全球大约 1%的人口。认知缺陷是该疾病的一个主要特征，也是导致长期残疾的主要原因。在过去的几十年中，大量的文献积累表明精神分裂症存在早期听觉感知过程的损伤。在这篇综述中，我们首先从行为和神经生理学的角度描述精神分裂症中的早期听觉功能障碍，并研究它们与高阶认知结构和社会认知过程的相互关系。然后，我们提供了对潜在病理过程的深入了解，特别是与谷氨酸能和 N-甲基-D-天冬氨酸受体（NMDAR）功能障碍模型的关系。最后，我们讨论了早期听觉测量作为精确干预治疗靶点和病因研究翻译生物标志物的应用。总的来说，这篇综述指出了早期听觉缺陷在精神分裂症病理生理学中的关键作用，对早期干预和听觉靶向方法具有重要意义。
