酵母Ty病毒样颗粒。
The yeast Ty virus-like particles.
作者信息
Roth J F
机构信息
Retrovirus Molecular Biology Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
出版信息
Yeast. 2000 Jun 30;16(9):785-95. doi: 10.1002/1097-0061(20000630)16:9<785::AID-YEA550>3.0.CO;2-L.
Virus-like particle (VLP) assembly is a crucial step of the life cycle of retrotransposons. The S. cerevisiae Ty elements represent an interesting model for the analysis of these particles and thus have been studied extensively. Our current knowledge of the organisation and assembly of Ty1 and Ty3 VLPs is reviewed here. This includes the mechanism of assembly, the role of the Tya core protein during VLP formation and the RNA packaging process. The physical properties of Ty1 VLPs are also described and the latest three-dimensional Ty1 VLP reconstructions are shown. In addition, the relevance of these studies is discussed in the context of retro-element biology.
病毒样颗粒（VLP）组装是逆转座子生命周期中的关键步骤。酿酒酵母Ty元件是分析这些颗粒的一个有趣模型，因此已得到广泛研究。本文综述了我们目前对Ty1和Ty3 VLP的组织和组装的认识。这包括组装机制、Tya核心蛋白在VLP形成过程中的作用以及RNA包装过程。还描述了Ty1 VLP的物理特性，并展示了最新的三维Ty1 VLP重建。此外，在逆转元件生物学的背景下讨论了这些研究的相关性。
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