Livingston D H, Lavery R F, Passannante M R, Skurnick J H, Baker S, Fabian T C, Fry D E, Malangoni M A
Department of Surgery, Preventive Medicine and Community Health, New Jersey Medical School, Newark, New Jersey, USA.
Ann Surg. 2000 Jul;232(1):126-32. doi: 10.1097/00000658-200007000-00018.
To determine the negative predictive value of cranial computed tomography (CT) scanning in a prospective series of patients and whether hospital admission for observation is mandatory after a negative diagnostic evaluation after minimal head injury (MHI).
Hospital admission for observation is a current standard of practice for patients who have sustained MHI, despite having undergone diagnostic studies that exclude the presence of an intracranial injury. The reasons for this practice are multifactorial and include the perceived false-negative rate of all standard diagnostic tests, the belief that admission will allow prompt diagnosis of occult injuries, and medicolegal considerations about the risk of early discharge.
In a prospective, multiinstitutional study during a 22-month period at four level I trauma centers, all patients with MHI were evaluated using the following protocol: a standardized physical and neurologic examination in the emergency department, cranial CT scanning, and then admission for observation. MHI was defined as either a documented loss of consciousness or evidence of posttraumatic amnesia and an emergency department Glasgow Coma Scale score of 14 or 15. Outcomes were measured at 20 hours and at discharge and included clinical deterioration, need for craniotomy, and death.
Two thousand one hundred fifty-two consecutive patients fulfilled the study protocol. The CT was interpreted as negative for intracranial injury in 1,788, positive in 217, and equivocal in 119. Five patients with CT scans initially interpreted as negative required intervention. There was one craniotomy in a patient whose CT scan was initially interpreted as negative. This patient had facial fractures that required surgical intervention and elevation of depressed intracranial fracture fragments. The negative predictive power of a cranial CT scan based on the preliminary reading of the CT scan and defined by the subsequent need for neurosurgical intervention in the population fully satisfying the protocol was 99.70%.
Patients with a cranial CT scan, obtained on a helical CT scanner, that shows no intracerebral injury and who do not have other body system injuries or a persistence of any neurologic finding can be safely discharged from the emergency department without a period of either inpatient or outpatient observation. Implementation of this practice could result in a potential decrease of more than 500,000 hospital admissions annually.
确定在一系列前瞻性研究患者中头颅计算机断层扫描(CT)的阴性预测值,以及在轻度头部损伤(MHI)后经过阴性诊断评估后是否必须住院观察。
对于遭受MHI的患者,尽管已经进行了排除颅内损伤的诊断性检查,但住院观察仍是当前的标准治疗方法。这种做法的原因是多方面的,包括所有标准诊断测试的假阴性率、认为住院将有助于及时诊断隐匿性损伤以及关于早期出院风险的法医学考虑。
在四个一级创伤中心进行的为期22个月的前瞻性多机构研究中,所有MHI患者均按照以下方案进行评估:在急诊科进行标准化的体格和神经学检查、头颅CT扫描,然后住院观察。MHI定义为有记录的意识丧失或创伤后遗忘的证据,且急诊科格拉斯哥昏迷量表评分为14或15分。在20小时和出院时测量结果,包括临床恶化、开颅手术需求和死亡情况。
2152例连续患者符合研究方案。CT显示颅内损伤阴性的有1788例,阳性的有217例,不明确的有119例。5例最初CT扫描显示阴性的患者需要干预。有1例最初CT扫描显示阴性的患者进行了开颅手术。该患者有面部骨折,需要手术干预并抬起凹陷的颅内骨折碎片。在完全符合方案的人群中,基于CT扫描初步解读并由后续神经外科干预需求定义的头颅CT扫描阴性预测能力为99.70%。
使用螺旋CT扫描仪进行的头颅CT扫描显示无脑内损伤且无其他身体系统损伤或任何神经学发现持续存在的患者,可以安全地从急诊科出院,无需住院或门诊观察。实施这种做法每年可能使住院人数减少超过50万。