Gilroy D W, Colville-Nash P R
Vascular Biology Research Center and Division of Hematology, University of Texas-Houston Medical School, 77030, USA.
J Mol Med (Berl). 2000;78(3):121-9. doi: 10.1007/s001090000094.
Cyclo-oxygenase (COX) is responsible for the synthesis of bioactive prostanoids, the inhibition of which serves as the basis for the mode of action of clinically used nonsteroidal anti-inflammatory drugs. While there were suggestions as early as the 1970s that an inducible isoform of COX exists, it was only in the early 1990s that COX 2 was identified, cloned and sequenced. Not surprisingly, this new isoform was expressed at sites of inflammation and reported to contribute to the inflammatory response. Recently, however, evidence is emerging to suggest that COX 2 also has anti-inflammatory properties. In this review, the two faces of COX 2 are examined, with emphasis on its role in regulating inflammatory resolution, including possible mechanisms of action
环氧化酶（COX）负责生物活性前列腺素的合成，对其抑制作用是临床使用的非甾体抗炎药作用方式的基础。早在20世纪70年代就有人提出存在一种可诱导的COX同工型，但直到20世纪90年代初COX 2才被鉴定、克隆和测序。不出所料，这种新的同工型在炎症部位表达，并据报道对炎症反应有促进作用。然而，最近有证据表明COX 2也具有抗炎特性。在这篇综述中，我们研究了COX 2的两面性，重点是其在调节炎症消退中的作用，包括可能的作用机制。
