Lennartz H, Trobisch H, Derra E, Krian A, Brüster H
Langenbecks Arch Chir. 1976 Nov 15;342:341-9. doi: 10.1007/BF01267393.
Two groups of patients suffering from pneumonitis received different treatments and were compared retrospectively. The first group (38 patients) was treated with heparin and aprotinin. The overall mortality was 50 percent; of the patients who were artifically ventilated 64 percent died. The second group (60 patients) was treated with heparin, fresh-frozen plasma, nicotinic acid, methylprednisolone, and alpha-receptor blocking agents. In this group the overall mortality was 26.5 percent and the mortality among the patients who were artificially ventilated was 33 percent. These results lead the authors to feel that the treatment of pneumonitis with aprotinin is no longer indicated.
两组肺炎患者接受了不同治疗并进行回顾性比较。第一组(38例患者)接受肝素和抑肽酶治疗。总死亡率为50%;接受人工通气的患者死亡率为64%。第二组(60例患者)接受肝素、新鲜冷冻血浆、烟酸、甲泼尼龙和α受体阻滞剂治疗。该组总死亡率为26.5%,接受人工通气的患者死亡率为33%。这些结果使作者认为不再推荐用抑肽酶治疗肺炎。