Flament M P, M'bisi R, Leterme P, Gayot A T
Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacotechnie Industrielle, Lille, France.
Drug Dev Ind Pharm. 2000 Jul;26(7):731-6. doi: 10.1081/ddc-100101291.
The objective of this work was to develop a galenic form of activated charcoal appropriate for the needs of clinical toxicology. To preserve the adsorption capacity of charcoal, we developed an extemporaneous preparation of activated charcoal intended for clinical toxicology. To improve the wettability of activated charcoal, we used densification by wet granulation. The presence of a viscosity agent is necessary to ensure the homogeneity of the suspension and its adhesiveness on gastric mucous membrane. Five formulations with different viscosity agents were prepared, and their adsorption capacity, wettability, viscosity, and adhesiveness were studied.
这项工作的目的是开发一种适合临床毒理学需求的活性炭药剂形式。为了保持活性炭的吸附能力，我们开发了一种用于临床毒理学的活性炭临时制剂。为了提高活性炭的润湿性，我们采用湿法制粒进行致密化处理。需要有一种增稠剂来确保悬浮液的均匀性及其在胃黏膜上的粘附性。制备了五种含有不同增稠剂的制剂，并对它们的吸附能力、润湿性、粘度和粘附性进行了研究。
