巨噬细胞对改变自身细胞的识别与裂解。I. 2,4,6-三硝基苯磺酸对靶细胞的修饰
Recognition and lysis of altered-self cells by macrophages. I. Modification of target cells by 2,4,6-trinitrobenzene sulphonic acid.
作者信息
Kunin S, Gallily R
出版信息
Immunology. 1983 Feb;48(2):265-72.
Abstract
Peritoneal exudate macrophages from normal, untreated or thioglycollate-elicited mice, lysed syngeneic fibroblasts and lymphoblasts modified by 2,4,6-trinitrobenzene sulphonic acid (TNBS) in vitro. Optimal lysis of the hapten-modified cells by elicited macrophages was usually seen after 18 hr of co-cultivation at E:T ratios of 10:1-30:1. Cytotoxicity was expressed by macrophages depleted of T cells, and was not potentiated by LPS. Allogeneic TNBS-modified cells were lysed by non-immune, non-activated macrophages to the same extent as syngeneic modified targets, indicating that genetic restriction does not appear to play a role in macrophage-mediated cytolysis of TNBS-modified cells.
摘要
来自正常、未处理或经巯基乙酸盐诱导的小鼠的腹腔渗出巨噬细胞，在体外可裂解经2,4,6-三硝基苯磺酸（TNBS）修饰的同基因成纤维细胞和淋巴母细胞。诱导的巨噬细胞对经半抗原修饰的细胞的最佳裂解通常在以10:1 - 30:1的E:T比例共培养18小时后可见。细胞毒性由耗尽T细胞的巨噬细胞表现出来，且不受LPS增强。非免疫、未激活的巨噬细胞对同种异体TNBS修饰细胞的裂解程度与对同基因修饰靶标的裂解程度相同，这表明基因限制似乎在巨噬细胞介导的TNBS修饰细胞的细胞溶解中不起作用。
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