Frey L G, Winter J C
Psychopharmacology (Berl). 1979 Mar 22;61(2):231-2. doi: 10.1007/BF00426741.
Separate groups of rats were trained to discriminate nefopam or morphine from saline in a two-lever operant task. Nefopam produced saline-appropriate responding in morphine-trained rats. The highest dose of morphine tested in nefopam-trained rats produced responding appropriate for neither training treatment. This intermediate morphine responding was antagonized by a naloxone treatment that had no effect on the nefopam discrimination. These results suggest that the stimulus properties of nefopam and morphine are qualitatively different but also that morphine produces effects related to those that result in stimulus control by nefopam.
将大鼠分成不同组，通过双杠杆操作性任务训练它们区分奈福泮或吗啡与生理盐水。奈福泮在吗啡训练的大鼠中产生了与生理盐水相符的反应。在奈福泮训练的大鼠中测试的最高剂量吗啡所产生的反应，对两种训练处理均不相符。这种中间的吗啡反应被纳洛酮处理所拮抗，而纳洛酮处理对奈福泮辨别无影响。这些结果表明，奈福泮和吗啡的刺激特性在性质上不同，但也表明吗啡产生的效应与那些导致奈福泮产生刺激控制的效应相关。
