Knutson B, Westdorp A, Kaiser E, Hommer D
Section of Brain Electrophysiology and Imaging, National Institutes of Health, Bethesda, Maryland, 20892-1610, USA.
Neuroimage. 2000 Jul;12(1):20-7. doi: 10.1006/nimg.2000.0593.
Comparative studies have implicated striatal and mesial forebrain circuitry in the generation of autonomic, endocrine, and behavioral responses for incentives. Using blood oxygen level-dependent functional magnetic resonance imaging, we sought to visualize functional activation of these regions in 12 normal volunteers as they anticipated and responded for monetary incentives. Both individual and group analyses of time-series data revealed significant activation of striatal and mesial forebrain structures (including insula, caudate, putamen, and mesial prefrontal cortex) during trials involving both monetary rewards and punishments. In addition to these areas, during trials involving punishment, group analysis revealed activation foci in the anterior cingulate and thalamus. These results corroborate comparative studies which implicate striatal and mesial forebrain circuitry in the elaboration of incentive-driven behavior. This report also introduces a new paradigm for probing the functional integrity of this circuitry in humans.
比较研究表明，纹状体和内侧前脑回路参与了对奖励的自主、内分泌和行为反应的产生。我们使用血氧水平依赖性功能磁共振成像，试图在12名正常志愿者预期并对金钱奖励做出反应时，可视化这些区域的功能激活情况。对时间序列数据的个体和组分析均显示，在涉及金钱奖励和惩罚的试验中，纹状体和内侧前脑结构（包括脑岛、尾状核、壳核和内侧前额叶皮质）有显著激活。除了这些区域，在涉及惩罚的试验中，组分析显示前扣带回和丘脑有激活灶。这些结果证实了比较研究，即纹状体和内侧前脑回路参与了奖励驱动行为的细化。本报告还引入了一种新的范式，用于探究人类该回路的功能完整性。
