Weisbart R H, Morris R I, Terasaki P I, Bluestone R, Goldberg L S
Clin Exp Immunol. 1976 Dec;26(3):441-8.
Lymphocyte responsiveness to IgG was measured by an agarose method in nine patients with ankylosing spondylitis (AS), one patient with Reiter's Syndrome (RS), and thirty-six of their family members. Similar studies were also performed in five patients with rheumatoid arthritis (RA) and twenty-nine of their first degree relatives as well as in seven control families (twenty-seven subjects). Lymphocytes from the ten spondylitic patients and twenty-four of thirty-six family members responded in vitro to autologous IgG. Although most of these subjects had the histocompatibility antigen, B27, there was no association between B27 and response to IgG. Four of the five patients with RA and twenty of their twenty-nine first degree relatives responded in vitro to IgG, whereas only six of twenty-seven control family members gave a positive reaction. There was no difference in the incidence of antiglobulins (detected by agglutination tests) in the family members of patients with AS and RA or in control family members. These data indicate that lymphocyte responsiveness to IgG is the only aberrant immune response thus far described which is shared by patients with AS and RA and their family members.
采用琼脂糖法检测了9例强直性脊柱炎（AS）患者、1例赖特综合征（RS）患者及其36名家庭成员的淋巴细胞对IgG的反应性。对5例类风湿关节炎（RA）患者及其29名一级亲属以及7个对照家庭（27名受试者）也进行了类似研究。10例脊柱关节病患者及36名家庭成员中的24人的淋巴细胞在体外对自身IgG有反应。虽然这些受试者大多数具有组织相容性抗原B27，但B27与对IgG的反应之间并无关联。5例RA患者中的4例及其29名一级亲属中的20人在体外对IgG有反应，而27名对照家庭成员中只有6人呈阳性反应。AS和RA患者家庭成员及对照家庭成员中抗球蛋白的发生率（通过凝集试验检测）并无差异。这些数据表明，淋巴细胞对IgG的反应性是迄今为止所描述的AS和RA患者及其家庭成员共有的唯一异常免疫反应。
