强直性脊柱炎患者血清中免疫复合物的检测
Detection of immune complexes in serum of patients with ankylosing spondylitis.
作者信息
Corrigall V, Panayi G S, Unger A, Poston R N, Williams B D
出版信息
Ann Rheum Dis. 1978 Apr;37(2):159-63. doi: 10.1136/ard.37.2.159.
Immune complexes were measured in the sera of 18 patients iwth ankylosing spondylitis and 5 normal control subjects by their ability to inhibit antibody-mediated lymphocyte-induced cytotoxicity. 11 of the spondylitis and none of the control sera contained circulating complexes. Fractionation of sera on Sephadex G-200 showed that complexes were of two molecular sizes, one of intermediate and the other of large molecular weight. The presence of immune complexes did not correlate with activity of disease or the presence of peripheral arthritis although the one patient with polyarthritis had the highest level of complexes detected in this study. The nature of the antigen in these antigen-antibody complexes is of great interest since it may provide evidence of the aetiological agent in the disease.
通过检测18例强直性脊柱炎患者和5例正常对照者血清中免疫复合物抑制抗体介导的淋巴细胞诱导细胞毒性的能力来测定免疫复合物。11例脊柱炎患者的血清中含有循环免疫复合物，而对照血清中均未检测到。血清在葡聚糖凝胶G - 200上进行分级分离显示，复合物有两种分子大小，一种为中等分子量，另一种为大分子分子量。尽管在本研究中检测到多关节炎患者的免疫复合物水平最高，但免疫复合物的存在与疾病活动度或外周关节炎的存在并无相关性。这些抗原 - 抗体复合物中抗原的性质备受关注，因为它可能为该疾病的病原体提供证据。
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