McDougall J J, Pawlak M, Hanesch U, Schmidt R F
McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, 3330 Hospital Drive NW,., T2N 4N1, Calgary AB, Canada.
Neurosci Lett. 2000 Jul 14;288(2):123-6. doi: 10.1016/s0304-3940(00)01211-8.
The peripheral effects of nociceptin were examined in normal and acutely inflamed rat knee joints by analyzing single unit recordings from articular primary afferents in response to normal and extreme rotation of the knee. Bolus close intraarterial injection of nociceptin (0.01, 1 and 100 microM) caused a sensitization of normal and inflamed knee joint afferents in response to movements in the normal working range of the joint. When the joint was hyper-rotated, nociceptin had no significant effect on afferent discharge rate in normal knees, however, in inflamed joints the top dose of the neuropeptide caused a decrease in articular mechanosensitivity. These findings suggest that nociceptin seems to be involved in the control of peripheral nociceptive mechanisms, although the behaviour of the peptide is dependent upon the inflammatory status of the tissue.
通过分析关节初级传入神经对膝关节正常和极度旋转的反应的单单位记录，研究了正常和急性炎症大鼠膝关节中孤啡肽的外周效应。动脉内团注孤啡肽（0.01、1和100微摩尔）导致正常和炎症膝关节传入神经对关节正常工作范围内运动的敏感性增加。当关节过度旋转时，孤啡肽对正常膝关节的传入放电率无显著影响，然而，在炎症关节中，该神经肽的最高剂量导致关节机械敏感性降低。这些发现表明，孤啡肽似乎参与外周伤害性感受机制的控制，尽管该肽的行为取决于组织的炎症状态。
