Tracey I, Becerra L, Chang I, Breiter H, Jenkins L, Borsook D, González R G
Center for Functional MRI of the Brain, Oxford University, Clinical Neurology Department, John Radcliffe Hospital, OX3 9DU, Oxford, UK.
Neurosci Lett. 2000 Jul 14;288(2):159-62. doi: 10.1016/s0304-3940(00)01224-6.
We used functional magnetic resonance imaging (fMRI) to determine whether similar brain regions activate during noxious hot and cold stimulation. Six male subjects underwent whole brain fMRI during phasic delivery of noxious hot (46 degrees C) and noxious cold (5 degrees C) stimulation to the dorsum of the left hand. Mid-brain regions activated included thalamus, basal ganglia and insula. Cortical areas activated included cingulate, somatosensory, premotor and motor cortices, as well as prefrontal and inferior parietal cortex. Most regions activated bilaterally but with stronger activation contralateral to the stimulus. Noxious cold stimulation produced significantly increased volumes of activation compared to noxious heat in prefrontal areas only. Our results suggest a similar network of regions activate common to the perception of pain produced by either noxious hot or cold stimulation.
我们使用功能磁共振成像（fMRI）来确定在有害热刺激和冷刺激期间是否有相似的脑区被激活。六名男性受试者在对左手背进行阶段性有害热刺激（46摄氏度）和有害冷刺激（5摄氏度）时接受了全脑fMRI检查。激活的中脑区域包括丘脑、基底神经节和脑岛。激活的皮质区域包括扣带回、体感皮层、运动前区和运动皮层，以及前额叶和顶下小叶皮层。大多数区域双侧激活，但刺激对侧的激活更强。仅在前额叶区域，有害冷刺激比有害热刺激产生的激活体积显著增加。我们的结果表明，一个相似的脑区网络在有害热刺激或冷刺激所产生的疼痛感知中共同被激活。
