韩国人群中四个四聚体短串联重复序列（STR）基因座D18S1270、D14S608、D16S3253和D21S1437的频率数据。

Frequency data on four tetrameric STR loci D18S1270, D14S608, D16S3253 and D21S1437 in a Korean population.

作者信息

Choi M, Kim J H, Lee D H, Lee S H, Rho H M

机构信息

Department of Molecular Biology, and Research Center for Cell Differentiation, Seoul National University, Korea.

出版信息

Int J Legal Med. 2000;113(3):179-80. doi: 10.1007/s004140050294.

DOI:10.1007/s004140050294

PMID:10876993

Abstract

We present the results of a population study in Korea for four new tetrameric short tandem repeat (STR) loci employing multiplex PCR amplification, polyacrylamide gel electrophoresis of the PCR products and silver staining, which allow single base pair resolution and rapid typing. The loci tested were D18S1270, D14S608, D16S3253 and D21S1437 and all loci showed no significant deviations from Hardy-Weinberg equilibrium in more than 100 unrelated Koreans. This allelic frequency data can be used in forensic analyses and paternity tests to estimate the frequency of a multiplex PCR based DNA profile in the Korean population.

摘要

我们展示了一项在韩国针对四个新型四聚体短串联重复序列（STR）位点开展的群体研究结果。该研究采用多重PCR扩增、PCR产物的聚丙烯酰胺凝胶电泳及银染技术，这些技术可实现单碱基对分辨及快速分型。所检测的位点为D18S1270、D14S608、D16S3253和D21S1437，在100多名无亲缘关系的韩国人中，所有位点均未显示出与哈迪-温伯格平衡有显著偏差。该等位基因频率数据可用于法医分析和亲子鉴定，以估算韩国人群中基于多重PCR的DNA图谱的频率。