Griswold D E, Heppner G H, Calabresi P
Cancer Res. 1975 Jan;35(1):88-92.
5-Iodo-2'-deoxyuridine markedly stimulates the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells in C3HeB/FeJ and A/J male and female mice. The degree of stimulation is dose dependent over a range of 50 to 200 mg/kg. Stimulation is observed when drug is given on the day of antigen administration, or up to 3 days thereafter, but not when given before antigen administration or 4 days thereafter. The stimulatory effect of IUdR given on day 2 after antigen is still noted on Day 15, but the time of HPFC production is not prolonged beyond that in controls. Both 19S and 7S HPFC are increased, although the effect on the latter is less pronounced. In addition to stimulating production of HPFC in immunized animals, 5-iodo-2'-deoxyuridine increases background HPFC production in nonimmunized mice by 250% when assayed on the day after treatment.
5-碘-2'-脱氧尿苷能显著刺激C3HeB/FeJ和A/J雄性及雌性小鼠针对绵羊红细胞产生溶血素空斑形成细胞（HPFC）。在50至200毫克/千克的剂量范围内，刺激程度呈剂量依赖性。当在抗原给药当天或之后3天内给药时可观察到刺激作用，但在抗原给药前或之后4天给药则无此作用。抗原给药后第2天给予IUdR的刺激作用在第15天仍可观察到，但HPFC产生的时间并未延长至超过对照组。19S和7S HPFC均增加，尽管对后者的作用不太明显。除了刺激免疫动物产生HPFC外，5-碘-2'-脱氧尿苷在处理后第二天检测时，能使未免疫小鼠的背景HPFC产生增加250%。
