Philips Respironics, Respiratory Drug Delivery Ltd, Chichester, United Kingdom.
J Aerosol Med Pulm Drug Deliv. 2010 Apr;23 Suppl 1(Suppl 1):S45-54. doi: 10.1089/jamp.2009.0777.
The time requirements for multiple daily nebulizer treatments are important impediments to the quality of life for most patients with cystic fibrosis (CF). The I-neb Adaptive Aerosol Delivery (AAD) System can be used with a new mode of breathing during inhalation of aerosol, the Target Inhalation Mode (TIM). As a function of the TIM algorithm, the patient is guided to a slow and deep inhalation, which can result in shorter treatment times.
This study was conducted as a 3-month patient handling study of the I-neb AAD System in 42 patients with CF aged 12-57 years. The I-neb AAD System was supplied in both the standard Tidal Breathing Mode (TBM), and in TIM. Patients were trained to use the I-neb AAD System in TIM for the delivery of all their inhaled medications, but if they were not comfortable with the TIM maneuver they could change to the TBM maneuver. The primary variables were compliance with the correct use of the I-neb AAD System, and treatment times. The secondary variables were based on study questionnaires at the end of the study and covered ease of use, patient confidence, and patient satisfaction with the I-neb AAD System.
There were a total of 10,240 complete treatments and of these, 8979 (88%) were in TIM. Compliance with the correct use of the I-neb AAD System was 97.6%. The mean treatment time for complete treatments in TIM was 4.20 min, compared with 6.83 min when using the I-neb AAD System in TBM. The responses to the questionnaires indicated that over 77% of the patients found the I-neb AAD System in TIM to be either: very easy, easy, or acceptable to use.
The results demonstrated that by using the I-neb AAD System in TIM, a 40-50% reduction of nebulizer treatment times, and a high level of compliance could be achieved. The results also showed that the patients found the I-neb AAD System easy to use.
对于大多数囊性纤维化 (CF) 患者来说，每日多次雾化治疗所需的时间是影响生活质量的重要因素。I-neb 自适应雾化输送 (AAD) 系统可与吸气时的新呼吸模式（目标吸气模式 [TIM]）一起使用。作为 TIM 算法的一个功能，患者被引导进行缓慢而深的吸气，这可能导致治疗时间缩短。
这是一项为期 3 个月的 I-neb AAD 系统在 42 名 12-57 岁 CF 患者中的患者处理研究。I-neb AAD 系统同时提供标准潮气量呼吸模式 (TBM) 和 TIM。患者接受培训，使用 I-neb AAD 系统在 TIM 下输送所有吸入药物，但如果他们对 TIM 操作不适应，可以切换到 TBM 操作。主要变量是正确使用 I-neb AAD 系统的依从性和治疗时间。次要变量基于研究结束时的调查问卷，涵盖易用性、患者信心和患者对 I-neb AAD 系统的满意度。
共完成了 10240 次完整治疗，其中 8979 次（88%）采用 TIM。正确使用 I-neb AAD 系统的依从性为 97.6%。在 TIM 下完成完整治疗的平均治疗时间为 4.20 分钟，而在使用 I-neb AAD 系统的 TBM 下则为 6.83 分钟。问卷调查的回答表明，超过 77%的患者认为 I-neb AAD 系统在 TIM 下使用非常容易、容易或可以接受。
结果表明，通过在 TIM 下使用 I-neb AAD 系统，可以将雾化治疗时间缩短 40-50%，并实现高度的依从性。结果还表明，患者发现 I-neb AAD 系统易于使用。
