Bengtsson C, Johnsson G, Sannerstedt R, Werkö L
Br Med J. 1975 Jan 25;1(5951):197-9. doi: 10.1136/bmj.1.5951.197.
Chlorthalidone given to 40 hypertensive women significantly decreased blood pressure and serum potassium levels and increased the serum urate concentration. There were no individual correlations between the reduction in blood pressure and the decrease in serum potassium or the increase in serum urate. A reduction in dosage from 50 mg daily to 50 mg three times a week produced no significant changes in the diastolic or mean blood pressures though the systolic blood pressure was moderately increased. Concomitantly, serum potassium increased and serum urate decreased significantly on the lower chlorthalidone dose. We conclude that high doses of oral diuretics compared with lower ones are of limited further benefit and may increase the risk of clinically significant hypokalaemia and hyperuricaemia.
给予40名高血压女性氯噻酮后，血压和血清钾水平显著降低，血清尿酸盐浓度升高。血压降低与血清钾降低或血清尿酸盐升高之间无个体相关性。剂量从每日50毫克减至每周三次、每次50毫克后，舒张压或平均血压无显著变化，尽管收缩压有适度升高。同时，氯噻酮剂量降低时，血清钾升高，血清尿酸盐显著降低。我们得出结论，与低剂量口服利尿剂相比，高剂量口服利尿剂的进一步获益有限，且可能增加临床上显著低钾血症和高尿酸血症的风险。
