Materson B J, Oster J R, Michael U F, Bolton S M, Burton Z C, Stambaugh J E, Morledge J
Clin Pharmacol Ther. 1978 Aug;24(2):192-8. doi: 10.1002/cpt1978242192.
A multicenter study of chlorthalidone was performed to determine the relative antihypertensive efficacy and side effects of doses lower than those usually recommended for therapy. After a 4-wk placebo control period 100 patients with mild hypertension were randomly assigned doubleblind to 12.5-, 25-, 50-, or 75-mg regimens of chlorthalidone or to placebo for 12 wk. The groups of patients taking 25, 50, and 75 mg had declines in blood pressure which were not significantly different from each other. Serum potassium decreased in the 50- and 75-mg groups but not significantly in the 25-mg group. We conclude that chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg with less perturbation of potassium. Use of smaller initial diuretic doses may provide equal efficacy with fewer side effects for many patients.
开展了一项关于氯噻酮的多中心研究，以确定低于通常推荐治疗剂量的相对降压疗效和副作用。在为期4周的安慰剂对照期后，100例轻度高血压患者被随机双盲分配至氯噻酮12.5毫克、25毫克、50毫克或75毫克治疗方案组或安慰剂组，治疗12周。服用25毫克、50毫克和75毫克的患者组血压下降情况彼此无显著差异。50毫克和75毫克组血清钾降低，但25毫克组无显著降低。我们得出结论，每日25毫克氯噻酮治疗高血压的效果至少与50毫克和75毫克相同，且对钾的干扰较小。对许多患者而言，使用较小的初始利尿剂剂量可能会在副作用较少的情况下提供相同的疗效。
