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体温过低、凝血功能障碍和酸中毒。

Hypothermia, coagulopathy, and acidosis.

作者信息

Eddy V A, Morris J A, Cullinane D C

机构信息

Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

出版信息

Surg Clin North Am. 2000 Jun;80(3):845-54. doi: 10.1016/s0039-6109(05)70099-2.

Abstract

The management of patients requiring a damage control approach taxes the abilities of the best equipped trauma center. These patients present with severe metabolic abnormalities, most notably characterized by a deadly triad of hypothermia, coagulopathy, and acidosis. Using volumetric, oxymetric pulmonary artery catheters, hypothermia and any ongoing cardiovascular abnormalities can be identified quickly and treatment can be monitored. External, forced air rewarming is a valuable technique in treating the patient with hypothermia, as are more invasive modalities, including body cavity lavage. Although there is no shotgun approach to blood component transfusion therapy, the coagulopathy shown by these patients has a time course that is more rapid than stat laboratories can presently keep up with. Given the fulminant nature of this coagulopathy, the authors feel justified in empirically initiating platelet and plasma or cryoprecipitate transfusion on identification of visible coagulopathy. The willingness of trauma surgeons to push the envelope in treating these most severely afflicted patients has allowed patients who once would have certainly died to lead meaningful lives.

摘要

对需要采取损伤控制方法的患者进行管理,考验着设备最完善的创伤中心的能力。这些患者存在严重的代谢异常,最显著的特征是体温过低、凝血功能障碍和酸中毒这一致命三联征。使用容量测定、血氧测定的肺动脉导管,可以迅速识别体温过低和任何持续的心血管异常情况,并监测治疗效果。外部强制空气复温是治疗体温过低患者的一项有价值的技术,更具侵入性的方式,包括体腔灌洗,也是如此。虽然在血液成分输血治疗方面没有通用方法,但这些患者出现的凝血功能障碍的病程比目前即时检验实验室能够跟上的速度更快。鉴于这种凝血功能障碍的暴发性本质,作者认为在识别出明显的凝血功能障碍后凭经验开始输注血小板和血浆或冷沉淀是合理的。创伤外科医生愿意突破常规治疗这些病情最严重的患者,使得那些曾经肯定会死亡的患者能够过上有意义的生活。

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