仅一种类风湿因子同种型升高与类风湿关节炎患病率增加无关——一项基于人群的研究。
Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study.
作者信息
Jónsson T, Thorsteinsson J, Valdimarsson H
机构信息
Department of Immunology, National University Hospital, Landspítalinn Reykjavík, Iceland.
出版信息
Scand J Rheumatol. 2000;29(3):190-1. doi: 10.1080/030097400750002094.
OBJECTIVE
To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA.
METHODS
Serum samples, collected between 1973 and 1983 from nearly 14,000 randomly selected individuals, were screened for elevation of RF. In 1987, 173 RF positive and 156 matched RF negative participants were evaluated clinically.
RESULTS
Participants with elevation of only one RF isotype, most commonly IgM, did not have significantly higher prevalence of RA than the RF negative controls. Of the 17 RF positive individuals who were diagnosed with RA, 14 (82%) had a combined elevation of IgM and IgA RF.
CONCLUSION
In contrast to a combined elevation of IgM and IgA RF, elevation of only one RF isotype may not be a significant risk factor for the development of RA.
目的
分析不同类风湿因子（RF）同种型模式与类风湿关节炎（RA）患病率之间的关系。
方法
对1973年至1983年间从近14000名随机选取的个体中采集的血清样本进行RF升高筛查。1987年，对173名RF阳性参与者和156名匹配的RF阴性参与者进行了临床评估。
结果
仅一种RF同种型升高的参与者，最常见的是IgM，其RA患病率并不比RF阴性对照组显著更高。在17名被诊断为RA的RF阳性个体中，14名（82%）同时存在IgM和IgA RF升高。
结论
与IgM和IgA RF联合升高相反，仅一种RF同种型升高可能不是RA发生的显著危险因素。
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