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MK-826（L-749,345）对363株厌氧菌的体外活性。

In vitro activities of MK-826 (L-749,345) against 363 strains of anaerobic bacteria.

作者信息

Wexler H M, Molitoris D, Finegold S M

机构信息

Research Services, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA.

出版信息

Antimicrob Agents Chemother. 2000 Aug;44(8):2222-4. doi: 10.1128/AAC.44.8.2222-2224.2000.

DOI:10.1128/AAC.44.8.2222-2224.2000
PMID:10898709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC90047/
Abstract

The activity of MK-826 was compared to the activities of cefoxitin, ceftriaxone, imipenem, and meropenem against 363 gram-negative and gram-positive anaerobes by using NCCLS procedures. At least 98% of the strains were susceptible to the carbapenems. All strains of Clostridium perfringens, Fusobacterium nucleatum, Peptostreptococcus, and Sutterella wadsworthensis were susceptible to all agents tested.

摘要

采用美国国家临床实验室标准化委员会（NCCLS）的方法，将MK-826与头孢西丁、头孢曲松、亚胺培南和美罗培南针对363株革兰氏阴性和革兰氏阳性厌氧菌的活性进行了比较。至少98%的菌株对碳青霉烯类药物敏感。所有产气荚膜梭菌、具核梭杆菌、消化链球菌和沃兹沃思萨特菌菌株对所有测试药物均敏感。

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In vivo activity and pharmacokinetic evaluation of a novel long-acting carbapenem antibiotic, MK-826 (L-749,345).新型长效碳青霉烯类抗生素MK-826（L-749,345）的体内活性及药代动力学评价
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