Freedman R R, Dinsay R
Wayne State University School of Medicine, Detroit, Michigan, USA.
Fertil Steril. 2000 Jul;74(1):20-3. doi: 10.1016/s0015-0282(00)00563-x.
To determine the effects of clonidine, which reduces central sympathetic activation, on the sweating threshold in postmenopausal women with and without hot flashes.
Laboratory physiologic study.
University medical center.
PATIENT(S): 12 healthy postmenopausal women reporting frequent hot flashes and 7 reporting none.
INTERVENTION(S): In two separate sessions, participants received a blind intravenous injection of clonidine HCl (2 microg/kg of body weight) or placebo, followed by body heating.
MAIN OUTCOME MEASURE(S): Core body temperature, mean skin temperature, sweat rate, sternal skin conductance level, and blood pressure.
RESULT(S): Symptomatic women had significantly lower core body temperature sweating thresholds than asymptomatic women after receiving placebo. Clonidine significantly increased this threshold in symptomatic women but lowered it in asymptomatic women.
CONCLUSION(S): These results support the hypothesis that elevated brain norepinephrine levels reduce the sweating threshold in symptomatic women, thereby contributing to the initiation of menopausal hot flashes.
确定可降低中枢交感神经激活的可乐定对有潮热和无潮热的绝经后女性出汗阈值的影响。
实验室生理学研究。
大学医学中心。
12名报告频繁潮热的健康绝经后女性和7名报告无潮热的健康绝经后女性。
在两个单独的时段，参与者接受盐酸可乐定（2微克/千克体重）或安慰剂的盲法静脉注射，随后进行身体加热。
核心体温、平均皮肤温度、出汗率、胸骨皮肤传导水平和血压。
有症状的女性在接受安慰剂后，其核心体温出汗阈值显著低于无症状女性。可乐定显著提高了有症状女性的这一阈值，但降低了无症状女性的这一阈值。
这些结果支持以下假设，即脑去甲肾上腺素水平升高会降低有症状女性的出汗阈值，从而导致绝经潮热的发作。
