胰高血糖素：在糖尿病高血糖症中的作用。
Glucagon: role in the hyperglycemia of diabetes mellitus.
作者信息
Dobbs R, Sakurai H, Sasaki H, Faloona G, Valverde I, Baetens D, Orci L, Unger R
出版信息
Science. 1975 Feb 14;187(4176):544-7. doi: 10.1126/science.1089999.
PMID:1089999
Abstract
Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.
摘要
生长抑素对胰高血糖素的抑制作用可减轻或消除由生长抑素、四氧嘧啶或全胰切除术导致胰岛素缺乏的犬类的高血糖症。这表明，严重糖尿病性高血糖症的发生既需要胰高血糖素的存在（无论其由胰腺分泌还是新发现的胃肠道A细胞分泌），也需要胰岛素缺乏。抑制胰高血糖素可能会改善糖尿病的治疗性血糖调节。
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