Wangensteen O W
Surg Gynecol Obstet. 1975 Mar;140(3):434-42.
Surgeons will do well to remember that the two most important contributions to the growth and extension of surgery came from two disciplines, not then regarded as the most innovative. Anesthesia came from dentistry, the work primarily of W.T.G. Morton of Boston; prophylactic surgical antisepsis originated with the obstetrician Semmelweis, who developed a scheme of prophylactic chemical antisepsis that still remains the core of surgical antisepsis. In the mid 1880's, largely as a result of the work of Chamberland and others of the Pasteur school, surgeons in France and Germany substituted thermal for chemical antisepsis, whenever applicable. Whereas Lister's influence was tremendous in fostering acceptance of antisepsis by surgeons, by the end of his professorial career he had begun his capitulation to prophylactic antisepsis, which was complete by 1896 to the very practices that Semmelweis had proved the value of almost five decades previously. These were 19th century innovations. The greatest boon to surgery's advance in this century has been control of cellulitic infections through chemotherapeutic agencies, the sulfonamides and antibiotics. The tremendous upsurge of interest in research at the end of World War II brought surgeons to a fuller realization of the significant part they could play in the advance of their discipline. Intimate alignment of surgeons with physiologists of the circulation begot intracardiac surgery, a significant innovation with consequences of tremendous import for greater medicine's advance. Today, surgeons attacking the problem of tissue transplantation are aligning themselves with biochemists, geneticists, immunologists, experimental pathologists, and pharmacologists in their broad approach to the phenomenon of allograft rejection. The great extension of vascular surgery since World War II has made jewelers of surgeons of small tubular structures. The technical phases of these demanding operative procedures have largely been overcome. Solution of the biologic rejection phenomenon is awaited eagerly by all investigators, a discovery that will greatly enhance predictable success of transfer of skin as well as of organs. When will surgery experience another great catalytic forward thrust like that achieved through anesthesia, prophylactic antisepsis, and the antibiotics? No discipline in medicine can exist alone without privation. For its continuing advancement, surgery is dependent upon close and intimate relationships with many other medical disciplines. Apart from the enlightenment provided by a searching examination of the origins of our surgical discipline, the earnest and persistent pursuer will discover a lively pleasure and satisfaction that accrues as a special dividend.
外科医生最好记住,对外科手术的发展和拓展贡献最大的两项成果来自两个学科,而当时这两个学科并未被视为最具创新性的学科。麻醉学源自牙科,主要是波士顿的W.T.G. 莫顿的工作成果;预防性外科抗菌法源自产科医生塞麦尔维斯,他制定了一套预防性化学抗菌方案,至今仍是外科抗菌法的核心。在19世纪80年代中期,主要由于尚伯兰及巴斯德学派其他人员的工作,法国和德国的外科医生在适用的情况下用热力抗菌法取代了化学抗菌法。虽然李斯特在促使外科医生接受抗菌法方面影响巨大,但在其教授生涯结束时,他已开始向预防性抗菌法让步,到1896年已完全接受了塞麦尔维斯在近五十年前就已证明其价值的那些做法。这些都是19世纪的创新成果。本世纪对外科手术进展贡献最大的是通过化学治疗药物(磺胺类药物和抗生素)控制蜂窝织炎感染。第二次世界大战末期对研究的极大兴趣热潮使外科医生更充分地认识到他们在本学科发展中可以发挥的重要作用。外科医生与循环生理学家密切合作催生了心脏内手术,这是一项重大创新,对医学的更大进步具有极其重要的意义。如今,致力于解决组织移植问题的外科医生在广泛研究同种异体移植排斥现象时,正与生物化学家、遗传学家、免疫学家、实验病理学家和药理学家携手合作。自第二次世界大战以来血管外科的巨大发展使擅长处理小管道结构的外科医生成为了技艺精湛的能工巧匠。这些高要求手术操作的技术难题在很大程度上已被攻克。所有研究人员都急切期待解决生物排斥现象,这一发现将大大提高皮肤以及器官移植可预测的成功率。外科手术何时会经历另一次像通过麻醉、预防性抗菌法和抗生素所取得的那样巨大的催化性向前推动呢?医学中没有任何一个学科能在孤立无援的情况下存在。为了持续发展,外科手术依赖于与许多其他医学学科建立密切而紧密的关系。除了通过深入探究我们外科领域的起源所带来的启迪之外,真诚执着的探索者还会发现一种作为特殊回报而产生的生动乐趣和满足感。