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新冠病毒对非肺部器官影响的最新细胞和分子机制

The Latest Cellular and Molecular Mechanisms of COVID-19 on Non-Lung Organs.

作者信息

Askari Hamid, Rabiei Fatemeh, Lohrasbi Fatemeh, Ghadir Sara, Ghasemi-Kasman Maryam

机构信息

Student Research Committee, Babol University of Medical Sciences, Babol 47176-47745, Iran.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol 47176-47745, Iran.

出版信息

Brain Sci. 2023 Feb 27;13(3):415. doi: 10.3390/brainsci13030415.

Abstract

Understanding the transmission pathways of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will aid in developing effective therapies directed at the virus's life cycle or its side effects. While severe respiratory distress is the most common symptom of a coronavirus 2019 (COVID-19) infection, the virus is also known to cause damage to almost every major organ and system in the body. However, it is not obvious whether pathological changes in extra-respiratory organs are caused by direct infection, indirect, or combination of these effects. In this narrative review, we first elaborate on the characteristics of SARS-CoV-2, followed by the mechanisms of this virus on various organs such as brain, eye, and olfactory nerve and different systems such as the endocrine and gastrointestinal systems.

摘要

了解严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的传播途径将有助于开发针对该病毒生命周期或其副作用的有效疗法。虽然严重呼吸窘迫是2019冠状病毒病(COVID-19)感染最常见的症状,但已知该病毒也会对人体几乎每个主要器官和系统造成损害。然而,呼吸外器官的病理变化是由直接感染、间接感染还是这些影响的组合引起的,目前尚不清楚。在这篇叙述性综述中,我们首先阐述SARS-CoV-2的特征,接着介绍该病毒对脑、眼和嗅神经等各种器官以及内分泌和胃肠系统等不同系统的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66f1/10046222/889c1d559bcd/brainsci-13-00415-g001.jpg

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